الرئيسية / الفعاليات العلمية / ابحاث / The Short-Term follow up of Changes in Serum Leptin, Ghrelin, and HBA1c after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) Operation

The Short-Term follow up of Changes in Serum Leptin, Ghrelin, and HBA1c after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) Operation

Hana’a Addai Ali1, Asawer Hasan Najm1, Safauldeen Salim2*
1Kufa University, College of Science, Chemistry Department, AL-Najaf, Iraq.
2Kufa University, College of Medicine, AL-Najaf, Iraq.
*Corresponding Autor: Safauldeen Salim
Abstract
Introduction: Morbid obesity is connected with various health related problems, so treating obesity is
an essential clinical concern. Swedish subject obesity study with 10 years follow up showed that
surgical option is far better than conservative approach. Aim To assess changes in adipose hormones
and HbA
1c in obese patients after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB). Materials and
Methods the study was conducted on 25 subjects (14 females and 11 males), age 32±6, with BMI 52.01
± 3.5 Kg/m² underwent LRYGB during the period from June 2015 to the end of February 2016. Fasting
blood glucose (FBG), HbA
1c, serum level of Lept in and Ghrel in were measured before the operation,
2, 4 and 6 months after LRYGB procedure. Results At 6 months point following LRYGB, a significant
reduction in body weight and BMI (p< 0.001) was reported. The mean weight of the participants
decreased to 82.7 Kg, mean BMI decreased to 31.1 Kg/m
2 and mean fat % declined to 35.55%. The
mean loss in the EBL percent was 77.3 % and %Excess Weight Loss (EWL) was 39.9%. There was
significant reduction in FBG, HbA
1c and serum Leptin level (p< 0.001) with significant increase in
serum Ghrelin level (p<0.001).Conclusions LRYGB produced a rapid and significant weight loss and
improvement in glucose homeostasis within six months after surgery. It had resulted in significant
changes in the level of leptin and ghrel in. There were differences between males and females after 6
months of follow-up.
Keywords: Obesity, Bariatric surgery, Ghrelin, Leptin, Follow-up. Fasting blood Sugar, Excess weight
Loss

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