Hanaa addai Ali1, Ali Abbas Abo Algon2, Shukryia Shadhan Chyad3, Emad Abbas Jaffar Al-Mulla3
1Department of Chemistry, Faculty of Science, University of Kufa, P.O. Box 21, An-Najaf 54001, Iraq.
2Pathological Department, Alkafeel University College, An-Najaf 54001, Iraq.
3College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, 54003 Al-Kufa, Iraq.
Corresponding author. E-mail: [email protected]
Received: Sep. 16, 2017; Accepted: Nov. 6, 2017; Published: Nov. 30, 2017.
Citation: Hanaa addai Ali, Ali Abbas Abo Algon, Shukryia Shadhan Chyad, and Emad Abbas Jaffar Al-Mulla, Perilipin-1 Level as Risk Marker of
Insulin Resistance in Morbidly Obese Patients. Nano Biomed. Eng., 2017, 9(4): 285-290.
Morbid obesity is a serious health condition that can interfere with basic physical functions such as
breathing or walking. Those who are morbidly obese are at greater risk of illnesses including diabetes,
high blood pressure, sleep apnea, gastro esophageal reflux disease, gallstones, osteoarthritis, heart
disease, and cancer. This study was designed by taking 60 patients and 20 controls aged from 25
to 45 years with morbid obesity. A collection of samples was done by taking venous fasting blood
samples from the patients and healthy volunteers after an overnight fasting. Insulin resistance (IR)
was assessed using the homeostasis model assessment for insulin resistance (HOMA-IR), fasting
blood glucose (FBG), glycated hemoglobin A1c (HbA1c) and lipid profle kits were used to determine
these parameters. It was observed that the increase level of perilipin-1 led to insulin resistance
and hyperinsulinemia for 60 patients, while the level of perilipin-1 in 20 controls caused insulin
sensitivity. The increase of all studied parameters was concluded from the p-value, which was less
than 0.05. The results also indicated that the level of perilipin-1 could be considered a risk factor
for many diseases. It could cause accumulation of the bad cholesterol in vascular tissues leading to
atherosclerosis; it could cause changes in many factors in secretion, could cause insulin resistance and
then diabetes mellitus. The level of fatty acid coming from continuous lipolysis causes fatty liver and
Keywords: Obesity; Perilipin-1; Cholesterol; Body mass index (BMI); Lipid profle