الرئيسية / الفعاليات العلمية / ابحاث / Spectrophotometric determination of metoclopramide medicine in bulk form and in pharmaceuticals using orcinol as reagent

Spectrophotometric determination of metoclopramide medicine in bulk form and in pharmaceuticals using orcinol as reagent

Hanaa Khazal Abdulghareeb TAHA, Mohauman Mohammed AL-RUFAIE,* and Zahraa Yosif MOTAWEQ
Faculty of Science, Kufa University, Kufa Street 1, Najaf, Iraq

Abstract. A modern, accurate, simple and sensitive spectrophotometric procedure is tested for the appreciation of
metoclopramide medicine as perspicuous form, as well as in various kinds of pharmaceutical dosages. The procedure
depends on the interaction of metoclopramide (MCP) medicine and orcinol reagent by utilizing azo coupling reaction.
The orcinol in NaOH solution middle to give a latterly ligand which reacts with copper (II) to output the complex with
strong yellow color at 50°C. The resulting complex is water soluble, stable and can be determined spectrophotometrically
at wavelength 459 nm. The calibration curve absorbance
vs. concentration was established in the concentration range 0.6-
12 ppm, and the curve followed the Beer’s law in this range. The procedure precision is given by the average recovery of
99.91% sequentially, as well as by the average relative standard deviation 0.70%, related to the amount of drug. The
sensitivity is established at molar absorptivity 1.9044×10
4 l‧cm-1‧mol-1. The Sandell sensitivity is tested as 0.002 μg/cm2.
The analytical results for the tested procedure agree with the official procedure. The interferences from medicine additives
were tested. The established procedure is successfully examined on the appreciation of MCP in diverse kinds of
pharmaceuticals.
Keywords: metoclopramide medicine; orcinol; diazotization-coupling reaction; copper (II) complex.

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