الرئيسية / الفعاليات العلمية / ابحاث / Immune Response in Pregnant Women Infected with Acute Vaginal Abscess Caused by Staphylococcus Aureus and Trichomonas Vaginalis

Immune Response in Pregnant Women Infected with Acute Vaginal Abscess Caused by Staphylococcus Aureus and Trichomonas Vaginalis

ahMed abduljabbar jaloob aljanaby1, SaleeM alhadraawy2, Sukayna MuShattat3
Keywords: IL-3, Lactoferrin, Pathogens, PGE2, TGF-β1
ABStRACt
Introduction: Vaginal abscess in pregnant women caused
by
Staphylococcus aureus and Trichomonas vaginalis is one
of the most important disease, this infection is still medically
uncontrolled because of poor health awareness due to the
absence of personal hygiene in some women.
Aim: This study is aimed add evaluation of immune response
in pregnant women infected with acute vaginal abscess caused
by
S.aureus and T.vaginalis due to the determination of four
biomarkers level; Interleukin13 (IL-13), Prostaglandin E2 (PGE2),
Transforming growth factor
β1(TGF-β1) and Lactoferrin.
Materials and Methods: This is a case control study was done
in AL-Zahra hospital in AL-Najaf City, Iraq from January 2017
to November 2017. 120 pregnant women were included in this
study, 30 women infected with
S. aureus, 30 women infected with
T. vaginalis, 30 women infected with both pathogens (inclusion
criteria in this study) and 30 healthy pregnant women as control.
All other cases were excluded from this study. Enzyme Linked
Immunosorbent Assay (ELISA) technique was used in this study
to estimate biomarkers level in serum of pregnant women
infected with acute vaginal abscess.
Results: The results of the current study proved that there was
signifcant increase (P <0.05) in IL-3, PGE2 and TGF-
β1 levels
in serum of women infected with acute vaginal abscess caused
by
S.aureus, T.vaginalis and both pathogens as compared
with control; while, there was signifcant decrease (P <0.05)
in lactoferrin level in serum of pregnant women infected with
T.vaginalis as compared with women infected with S.aureus and
control.
Conclusion: The synergistically pathogenic effect of S.aureus
and T.vaginalis in pregnant women infected with acute vaginal
abscess lead to activation of T-cell and overproduction of IL-3,
PGE2 and TGF-β1 as a good signaling markers against infection.
In contrast, this synergistic effect leads to reduction of lactoferrin
level in the same women. That mean these women may be
susceptible to acute anemia that may be lead to abortion

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