الرئيسية / الفعاليات العلمية / ابحاث / Study the Level of Cytokine in Unexplained and Idiopathic Infertile Men

Study the Level of Cytokine in Unexplained and Idiopathic Infertile Men

Hayder L. F. AL-Msaid , Alaauldeen S. M. AL-Sallami
Biology Department, Faculty of science/ University of Kufa, Iraq
Abstract
Fertility in the male is dependent on the proper production of sperm cells. This process, called spermatogenesis is very complex and involves the synchronization of numerous factors. The presence of pro–inflammatory cytokines play important role in male infertility . Data analysis from unexplained infertility (n=50), idiopathic infertile men (Asthenozoospermia (n=50), Oligozoospermia (n=50)), and Normospermia fertile men as a control (n=26). Show a significant interleukin 17 level was reduced in unexplained infertility (mean± Std. Error 351.23±8.92 also reduced in Asthenozoospermia 286.76±18.61and Oligozoospermia 271.71±18.32 while significant increase was observed in Normospermia fertile men 390.74±5.43.
A negative correlation was found between interleukin 17 level, And the sperms concentration, Sperm Progressive motility percent and sperm normal morphology present in idiopathic infertile men respectively (r= -0.589, r = -0.584 and r = -0.544). And A negative correlation was found between interleukin 17 level and the sperms concentration , Sperm Progressive motility percent and sperm normal morphology present in unexplained infertile men Respectively (r= -0.467 , r = -0.324 and r = -0.307 ).
The result showed a significant TGFb1 level was reduced in unexplained infertility (mean± Std. Error 71.24± 1.19 also reduced in Asthenozoospermia 109.54±6.31and Oligozoospermia 202.22± 5.83 while significant increase was observed in Normospermia fertile men 68.3±0.52.
A negative correlation was found between TGFb1 level, And the sperms concentration, Sperm Progressive motility percent and sperm normal morphology present in idiopathic infertile men respectively (r= -0.444, r = -0.462 and r = -0.464). And A negative correlation was found between TGFb1 level and the sperms concentration , Sperm Progressive motility percent and sperm normal morphology present in unexplained infertile men Respectively (r= -0.693 , r = -0.234 and r = -0.399
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