University of Kufa Official Site – Faculty of Basic Education
NIBRAS YAHYA AL-SALLAMI, ATHRAA HARJAN AND ISRAA HARJAN
Department of Biology, Faculty of Science, Kufa University, Iraq
(Received 17 March, 2017; accepted 22 April, 2017)
Key words: Penicillium griseofulvum, Antibacterial agent, Crude fungal filtrate, Chloroform part
Abstract – This study aim to test the ability of penicillium griseofulvum on produce secondary metabolism
compounds and test the activity of this compounds in inhibition the growth of Pseudomonas aeruginosa,
Proteus Vulgaris, Enterococcus, Salmonella typhi, Staphylococcus aureus and Klebsiella pneumonia, also this study
aim to know the effect of fungal filtrate in some physiological and biochemical parameters of blood in male
of rats. Also, this study aims to a comparison between the effect of chloroform part of fungal filtrate
andcrude fungal filtrate with some antibiotic in inhibition the growth of bacteria. This study showed the
ability of penicillium griseofulvum on produced antibacterial agent which have high ability in inhibition the
growth of bacteria, also this study showed variation between the effect of chloroform part of fungal filtrate
and crude fungal filtrate. Comparison with some antibiotic in inhibition the growth of bacteria, of
chloroform part of fungal filtrate, was higher effected in inhibition the growth of bacteria with inhibition
zone was 37.5 mm while the OGmacil, crude fungal filtrate, Amoxicillin and Ampicillin were lees effected
which were to be 32mm, 23.8mm, 8.6 mm and 4.5 mm respectively, physiological and biochemical values
of blood in male of rats were variation between the group treated with Staphylococcus aureus bacteria, group
treated with crude fungal filtrate and group treated with bacteria and crude fungal filtrate.
