Home / Scientific activities / Researches / ASSESSMENT OF COMPOUNDED DOXORUBICIN IN CARDIAC TISSUE OF EXPERIMENTAL ANIMALS

ASSESSMENT OF COMPOUNDED DOXORUBICIN IN CARDIAC TISSUE OF EXPERIMENTAL ANIMALS

EXPERIMENTAL ANIMALS
Dhifaf Zeki Aziz1, Merza Hemza Homady1, Hussein Abdul Kadim2, Khalida K. Abbas Al-Kelaby3
Department of Biology, College of Science, Department of pharmacology and therapeutics, College of
medicine, Department of Clinical and Laboratory Sciences, College of Pharmacy, University of Kufa,
Iraq
Article received 19.11.2017, Revised 7.12.2017, Accepted 13.12.2017
ABSTRACT
Doxorubicin is one of the most important anticancer agents, but its clinical uses are limited due to
cardiotoxicity, the present study evaluated the effects of new derivatives of doxorubicin on cardiac tissue by the
measurement of serum cardiac troponin I (cTnI) and CK-BM assays as biomarkers as well as heart tissue after 3
weeks of treatment in albino mice. The results indicated that TnI was significantly elevated (P≤ 0.05) in all studied
groups when compared with the control, also serum CK-MB was significantly elevated (P≤ 0.05) in all studied groups
except that treated with a new compound when compared with the control group. The histopathological study of heart
tissue revealed that the treatment with this compound showed less changes in heart tissue.
Key words: Doxorubicin, troponin I, CK-BM,
histopathology

Check Also

Recycling Environmental Waste

Faculty of Science, Department of Biology Specialization Scientific activity: Biology / Type of scientific activity: …

Leave a Reply

Your email address will not be published. Required fields are marked *