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Synthesis and Characterization of Some New 1,3-Oxazepine and 1,3-Diazepine Derivatives Combined with Azetidine-2-one

Eman Hassan Sahap, Ruaa Wisam Adam*, Zahraa Lateef Razzaq
Chemistry Department, Faculty of Sciences, Iraq.
*Corresponding Author: Ruaa Wisam Adam
Abstract
This work involved prepared of some new series of chemical compounds of 1, 3-oxazepineand 1, 3-
Diazepine derivatives. First step reaction of sulfadiazine with 4-amino acetophenone product of Schiff
base (A) 4-((1-(4-aminophenyl) ethylidene) amino)-N-(pyrimidin-2-yl) benzenesulfonamide. Then, Schiff
base [A] enter reactions with chloro acetyl chloride to product four-membrane ring (B) 4-(2-(4-
aminophenyl)-2-methyl-3-oxoazetidin-1-yl)-N-(pyrimidin-2-yl)benzene sulfonamide (B) were condensed
with different aromatic aldehydes such as (p-hydroxybenzeldehyde, N,N-dimethylaminobenzeldehyde] in
ethanol absolute to give new Schiff bases derivatives [B
1-B2] respectively, Then the resulting imines
derivatives [B
1-B2] were reacted with malic anhydride in toluene to give new 1,3-oxazepine-4,7-dione
ring derivatives [B
1a-B2a] ,reaction 1,3-oxazepine[B2a] with Naphthyl amine to give 1,3-diazepine-4,7-
dione ring derivatives[C].All compounds were characterized by M.P and FT-IR spectroscopy, some of them
were characterized by
1H-NMR and C13NMR spectroscopy analysis.
Keywords

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