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Study of Catsper1 Protein Levels in Unexplained and Idiopathic Infertile Men

ABSTRACT
Catsper 1 is an important protein involved in calcium channel synthesis. These channels are essential for the
hyperactivity of sperm flagellum, chemotaxis towards the egg, capacitation and acrosome reaction. Data analysis from
unexplained infertility (n=50), idiopathic infertile men (Asthenozoospermia (n=50), Oligozoospermia (n=50)), and
Normospermia fertile men as a control (n=26). The expression of CatSper1 protein expression in spermatozoa was
reduced in unexplained infertility (mean± SD. Error 64.32±2.5 and in Asthenozoospermia 46.6±2.1and Oligozoospermia
53.86±4.1 while significant increase was observed in Normospermia fertile men 115.19±2.3. CatSper1 protein
expressions was shown to have a positive correlation between sperm concentration, Sperm Progressive motility
percentage and sperm normal morphology present in idiopathic infertile men respectively (r= 0.822, r = 0.651 and r =
0.742). A positive correlation was found between CatSper1 protein expression and sperm concentration, Sperm
Progressive motility percentage and sperm normal morphology present in unexplained infertile men Respectively (r=
0.845, r = 0.576 and r = 0.582). The present study shows the importance of protein catsper 1 in infertile men and its
positive correlation with sperm parameters.

Hayder L F AL-Msaid

Alaauldeen S M AL-Sallami

Available online on www.ijpqa.com

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