الرئيسية / الفعاليات العلمية / Spectrophotometric Determination of Enalapril maleate bу Using1, 2 Naphthaquinolinc-4- Sulphonate Sodium Reagent

Spectrophotometric Determination of Enalapril maleate bу Using1, 2 Naphthaquinolinc-4- Sulphonate Sodium Reagent

NeuroQuantology |September 2022 | Volume 20 | Issue 10 |Page 10014-10030|doi: 10.14704/nq.2022.20.10.NQ55975
Walaa M. Najem et al/ Spectrophotometric Determination of Enalapril maleate bу Using1, 2 Naphthaquinolinc-4-Sulphonate Sodium Reagent
eISSN1303-5150 www.neuroquantology.com
Introduction
Spectrophotometric Determination of Enalapril
maleate bу Using1, 2 Naphthaquinolinc-4-
Sulphonate Sodium Reagent
Walaa M. Najem1, Sami Wheed Radhi 2 ,
1The Iraqi Ministry of Health, Najaf Health Department.
2Department of Chemistrу, Facultу of Science, Kufa Universitу, AL-Najaf- Iraq
1Email: walaa.90.mohamad@gmail.com
Abstract
In this study, simple and sensitive spectrophotometric method for the determination of Enalapril maleate (ENP) in
pharmaceutical formulations was reported. The proposed method was based on the reaction between (ENP) and 1,
2-naphthoquine-4-sulphonate (NQS) at alkaline medium (pH= 12) to form deep red product. Beer’s law was obeyed
in the range of (5-47.5 ) μg.mL-1 of Enalapril maleate at maximum wavelength of 518 nm. Under optimized reaction
conditions, linear regression equation of the calibration curve was y = 0.0179 x + 0.1888 (μg.mL-1) with a linear
correlation coefficient of 0.9988. The limit of detection (LOD) and limit of quantification (LOQ) were found to be
0.3351 μg.mL-1 and 1.1173 μg.mL 1, respectively. The method was successfully applied to the determination of
(ENP) in pharmaceutical formulations.
Keywords: Spectrophotometric; Enalapril maleate (ENP), pharmaceutical formulation; 1-2- naphthoquine-4-
sulfonate (NQS

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