الرئيسية / الفعاليات العلمية / reparation and use of a new organic Reagent of 4-(Furan-2- yldiazenyl)-3-hydroxy naphthalene-1-sulfonic acid (FDHNSA) In An Analytical study of some Metal ions and Drugs, such as salbutamol (SAL) and methyldopa (MDP).

reparation and use of a new organic Reagent of 4-(Furan-2- yldiazenyl)-3-hydroxy naphthalene-1-sulfonic acid (FDHNSA) In An Analytical study of some Metal ions and Drugs, such as salbutamol (SAL) and methyldopa (MDP).

ISSN: 09758585
May June 2022 RJPBCS 13(3) Page No. 170

Research Journal of Pharmaceutical, Biological and Chemical
Sciences

Preparation and use of a new organic Reagent of 4(Furan2
yldiazenyl)3hydroxy naphthalene1sulfonic acid (FDHNSA) In An
Analytical study of some Metal ions and Drugs, such as salbutamol
(SAL) and methyldopa (MDP).

Sami WRadhi, Abd Ali A.shalan*.

Faculty of Science, Department of Chemistry, Kufa University / AL Najaf / Republic of Iraq.

ABSTRACT

This study includes the synthesis of organic reagent 4(Furan2yldiazenyl)3hydroxy
naphthalene lsulfonic acid (FDHNSA) by reacting a diazonium Salt (4amino3hydroxy naphthalene1
sulfonic aciel) with Furan in alkaline ethanol solution. The prepared reagent was identified by using (UV
Vis), (FT.IR), (H1NMR) techniques, it was 𝜆𝑚𝑎𝑥 =412 nm for the reagent (FD HNSA) in ethanol. The melting
point of reagent (FDANSA) is found to be (129130)°C. This study tried to find a quick, easy and
inexpensive spectral way to detection two kind of drugs, Methyldopa (MDP) and Salbutamol (SAL)
through the reaction the drugs with anew regent 4(furan2yldiazenyl)3hydroxynaphthalene1
sulfonic acid (FDHNSA) in alkaline medium. The results a highest absorption for (SAL) with FDHNSA at
𝜆𝑚𝑎𝑥 =485 nm, while the 𝜆𝑚𝑎𝑥 = 348 nm for SAL in water, the highest absorption for the Free reagent (FDH
NSA) 𝜆𝑚𝑎𝑥 = 412 nm in ethanol. This study was conducted to find the optimized Conditions to estimate,
the drug (SAL) with the new Reagent (FDHNSA), It was show the Optimized Concentration reagent was
equal to (0.023M) and (2.5ml), The volume of drug (SAL) was equal to (1.5ml). The value of pH was equal
(11). Added to that the effect of temperature and time were Conducted, a higher absorbance was obtained
when temperature At (35°C), while at that best time it was obtained at (15min) for (SAL). The Calibration
curve for the durg (SAL) was Constructed after establish the optime conditions. The Calibration Curve
was constructed and subsequently the Beer’s Low was obeyed within the Concentration range of SAL
(0.75 12 𝜇𝑔. 𝑚𝑙1). The Molar absorptivity (𝜀) Value was equal 1.5802 × 10+4𝐿. 𝑚𝑜𝑙𝑒1. 𝑐𝑚1. The
Sandell’s sensitivity value was equal 0.0365 𝜇𝑔. 𝑚𝑙1. The R.SD% value was equal. 1.230% with a
correlation coefficient 0.9995. The stoichiometry of the reaction between the drug (SAL) and reagent
(FDHNSA) was proposed with continuous variation and mode ratio methode was (1:1) ,( SAL:FDHNSA).
Finally, interference was studied. The results reveal no effect on the determination of the drug This
methods was success fully applied for the determination of the drugs and in pharmaceutical compounds.
All materials used in the search are from the company B. D. H, Fluka, RiedelDheang seelzHannover, and
Merk.

Keywords: organic reagent, FDHNSA, SAL

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