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The assessment of Dystrophin and Titin in premenopausal thyroid women patients

Zahraa Shakir Mahmod 1 and Haider Salih Jaffat 2
1Basic Medical Sciences Branch, College of Dentistry, University
of Kerbala, Iraq.
2Department of Biology, Faculty of Science, University of Kufa,
Iraq.
*Corresponding author:
zahraa. sh@uokerbala. edu. iq
Abstract
The aim, this study was designed to investigate the relationships
between Dystrophin and Titin in patients with thyroid dysfunction.
Materials and methods. The study included 90 patients;
aged between 15 and 45 years, divided into three groups, 60
patients with thyriodism and 30 healthy subjects were taken as
control group, all patients (n=60) were divided into two groups
hypothyroidism and hyperthyroidism. This cross-sectional
study was carried out in Al-Fadel foundation for training and
development (research foundation) in Babylon province. Using
5 ml disposable syringes, healthy controls and patients were
randomly punctured for blood samples. Blood was placed in a
centrifuge tube and allowed to coagulate for 15 minutes before
being spun for 10 minutes at 1000 xg to 2000 xg to separate the
serum for immunological testing.
Results. The Mean Serum Titin levels which indicated significant
differences in studied groups of hypothyroidism, and hyperthyroidism
patients, and the control groups. Remark that
Titin levels decreased in Hypothyroidism and hyperthyroidism
groups less than in the healthy control group.
The statistical analysis results of Serum Dystrophin levels found
significant differences in the three groups studied. These results
revealed a significant decline in hypothyroidism patients, and
hyperthyroidism patients, compared with the healthy control
group, while Dystrophin level was increased in hypothyroidism
more than in the hyperthyroidism patients.
Conclusion. The results of T3, T4 &TSH level showed significant
differences after the comparison between hyperthyroidism,
hypothyroidism and control. There are significant
differences in the levels of DMD and TTN in comparison between
Hyperthyroidism, and Hypothyroidism as well as with
control.

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