Faculty of Science – University of Kufa Official Site – Faculty of Science
Lina A.Hassan
Department of Laboratory Investigations, Faculty of Science, University of Kufa
Ali A.Majeed
Department of Laboratory Investigations, Faculty of Science, University of Kufa
Mayyada F. Darweesh
Department of Biology, Faculty of Science, University of Kufa
Keywords:
burn sepsis, P. aerogenosa, antibiotic sensitivity, IL-10
Abstract
From December 2020 to November 2021, 60 patients entered the Al Sadder hospital in Al Najafprovince, Iraq. The patients were divided into two groups: 40 with pseudomonas aeruginosa and20 uninfected. The purpose of this study was to identify the function of the anti-inflammatorycytokine interleukin 10 (IL-10) in the pathophysiology of burn injuries. The patients were dividedinto two groups based on gender (34 males and 26 females) and age (1-61) years. To eliminatepatients who had received antibiotic medication during the sample collection. There was asignificant difference between males and females in this study, with the highest frequency ofpatient age being 16-30 (36.6 %), followed by 31-45 (30 %), 1-15 (23.4 %), and 46-61 (10%).Allpatients divided according to total degree of burn . However, P. aerogenosa antibiotic sensitivitytest, in contrast most bacterial isolates exhibited high resistance to Ceftazidime (90%) Tobramycin(80%) and Gentamicin (80%), whereas resistance to Ciprofloxacin (50%) Amikacin (40%) andPipracillin (70%) was variable finally less resist to TC (20%) and no resistance toward IMP (0 %).The study found that patients with P.aerogenosa infection had a substantially higher mean bloodconcentration of IL-10 (61.4 ± 11.8) than healthy controls (4.58 ± 0.77), whereas noninfectedpatients had a concentration of (18.21 ± 3.5 )pg/ml and non-infected patients had a concentrationof (4.5 ± 0.06) pg/ml.
