Faculty of Science – University of Kufa Official Site – Faculty of Science
Z.A. Umran1, A.H Abbas Hadi1, A.R. Mohammad *2
1- Department of Laboratory Investigations, Faculty of Science, University of Kufa, Najaf, Iraq
2- Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Najaf, Iraq
Keywords: Beta Catenin [MeSH], Colorectal Cancer [MeSH], Serum marker [MeSH]
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Article Type: Original Research | Subject: Diagnosis and Treatment of Veterans or Handicapped Diseases
Received: 2022/03/1 | Accepted: 2022/04/28 | Published: 2022/05/30
* Corresponding Author Address: Department of Pharmacology and therapeutics, Faculty of Medicine, University of Kufa, Najaf, Iraq. Postal Code: 21 (ealkhazaaly@gmail.com)
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Introduction
Cancer is a term used to describe a group of disorders in which aberrant cells proliferate and spread uncontrollably. Colorectal cancer (CRC) is a type of cancer that begins in the colon or rectum. Colon and rectal cancers are frequently lumped together because they share many characteristics [1].
It is currently the most frequent malignant cancer of the gastrointestinal system, accounting for 13% of all malignant tumors, and it is the second most common cause of death from cancer worldwide, affecting men and women equally [2]. There was a steady rise in numbers of CRC in Iraq in the last years. According to Iraq Cancer Board (ICB), CRC contributes about 6.15% for both genders, from all other cancer recorded in Iraq in 2018, in males was 7.52% and in females was 5.13% [3].
Biomarkers are molecular patterns which can be used to detect early-stage cancer and to tailor CRC treatment. They are classified as diagnostic, prognostic, or predictive. Thus, biomarkers are useful at various stages of the disease in determining disease progression and recurrence, as well as serving as a personalized indicator of therapeutic efficacy [4].
β-catenin is 90 kD multifunctional protein encoded by CTNNB gene. It is involved in cell adhesion and is also a component of the Wnt signaling pathway [5]. The Wnt/β-catenin signaling pathway is a highly conserved evolutionary route that regulates the embryonic pattern of bodily axes, stem cell fate, and tissue homeostasis [6].
Numerous studies indicate a link between β-catenin and cancer in a variety of tumour types including breast, hepatocellular, renal, CRC, and acute myeloid leukemia [7-13]. The aim of this study was to clarify the relationship between β-catenin levels in sera and some clinical and pathological variables in CRC patients, as well as explore the link between this biomarker and disease diagnosis and progression.
