Faculty of Science – University of Kufa Official Site – Faculty of Science
A doctoral thesis in the Department of Chemistry examined the evaluation of inflammatory markers as possible roles of complications in patients with spleen-removed and non-spleen-removed beta-thalassemia.
The thesis presented by the researcher Ayat Saeed Awad aims to evaluate the markers of immunoasphrologic inflammation TFF3, Metrnl, Cx3cl1, LL37 in the serums of beta thalassemia major patients who have removed the spleen and not removed and compare them with the healthy group matching them by age and sex. The results of the thesis showed a significant increase in the levels of Cx3cl1 and TFF3, especially in the group of thalassemia patients with spleen removal compared to non-spleen-removed patients, and a significant decrease in insulin, metrnl, LL-37 sensitivity in thalassemia major patients with spleen, which is a possible indicator of pathological progress leading to poor complications for this group of patients.
