The Plasma soluble corin is a key transmembrane serine protease, its principal functions is the synthesis of mature atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), these proteins have important functions in maintaining salt–water balance, blood pressure and cardiac function.
Plasma soluble corin has been suggested to be associated with hypertension and obesity by cell and animal-based studies. However, the relationship remained unclear. In the present study, an attempt is carried out to estimate the level of plasma soluble corin in ischemic heart disease (IHD) patients and compare their levels with the healthy control group in addition to the study the correlation between plasma soluble corin and hypertention and body mass index in ischemic heart disease in male patients.
One hundred and thirty six patients male patients with ischemic heart diseases including stable angina (AS), unstable angina (UA) and myocardial infarction (MI) (aged 35- >60 years) were involved in the present study during their admission to Al- Sader Teaching Hospital / Al- Najaf Al- Ashraf. Also patients groups were divided according to hypertention for the purpose of study the correlation between plasma soluble corin and this risk factor in ischemic heart disease. Body mass index, blood pressures and plasma soluble corin were determined in 176 participants aged above 35 years. Age matched forty healthy men were included as control group.
Results of the present study in general revealed that there was significant decrease (P<0.05) in plasma soluble corin in MI, UA and SA patients in comparing with healthy control group. The blood pressure (systolic and diastolic) revealed a significant negative correlation (P<0.05) with plasma soluble corin in all IHD patients groups. The body mass index showed a significant negative correlation (P<0.05) with plasma soluble corin in all IHD patients groups.
From the results of the study, we can conclude that the early detection of abnormal biochemical parameters include plasma soluble corin can limit complication and deterioration of hypertensive patients with ischemic heart disease. This finding suggests that corin may play a role in the pathology of hypertension and obesity.
Dr. Suaad M. J. Al-Hadrawy